CAD031

CAD031: A Promising Neuroprotective Compound for Alzheimer’s and Aging-Related Brain Health

Overview
CAD031 is an innovative, orally active compound designed to target key pathways involved in brain health and neurodegeneration. As a derivative of the Alzheimer’s-focused agent J147, CAD031 demonstrates enhanced activity in promoting neural stem cell function and neuroprotection. This molecule is capable of crossing the blood-brain barrier, making it especially effective in supporting brain cellular metabolism and function.

Mechanism of Action
CAD031 activates the AMPK/ACC1 signaling pathway, a crucial regulator of energy balance and lipid metabolism in the brain. By stimulating AMPK and inhibiting acetyl-CoA carboxylase 1 (ACC1), CAD031 increases acetyl-CoA availability, improves mitochondrial function, and reduces free fatty acid synthesis. These effects collectively contribute to enhanced brain cell survival, neurogenesis, and cognitive function.

Neuroprotective and Cognitive Benefits
Research shows that CAD031 has significant neuroprotective properties. In laboratory studies, it promotes the expression of neurogenesis markers such as Nestin, Pax6, DCX, and Ki67 in human neural precursor cells, indicating its role in stimulating the growth and development of new neurons. Furthermore, CAD031 protects neural cells against amyloid-beta and glutamate-induced toxicity, two major contributors to Alzheimer’s disease and other neurodegenerative conditions.

In Vivo Efficacy
Animal studies highlight CAD031’s ability to improve memory and cognitive function. In Alzheimer's disease mouse models, daily dietary administration of CAD031 for six months enhanced fear conditioning and spatial memory. It also increased the proliferation of neural precursor cells in critical brain regions like the dentate gyrus and subventricular zone without altering amyloid plaque levels. Additionally, CAD031 extended lifespan and maintained mitochondrial gene expression in aging mice, further supporting its potential as an anti-aging therapeutic.

Key Features and Specifications

Molecular Formula: C18H14F6N2O2

Molecular Weight: 404.31 g/mol

Appearance: Light yellow solid

CAS Number: 2071209-49-7

Solubility: Highly soluble in DMSO

Storage: Stable for years under proper refrigeration (powder at -20°C)

Applications in Research
CAD031 is extensively used in studies focusing on Alzheimer's disease, age-related neurodegeneration, mitochondrial dysfunction, and neural stem cell biology. Its role in activating AMPK and modulating lipid metabolism makes it a valuable compound in exploring new therapeutic strategies for brain health.

Why Choose CAD031 for Your Neurodegenerative Research?

Crosses the blood-brain barrier efficiently

Enhances neurogenesis and neural regeneration

Protects against toxic amyloid-beta and glutamate effects

Improves mitochondrial health and energy metabolism

Demonstrates lifespan extension effects in aging models

By integrating CAD031 into your research or product line, you gain access to a cutting-edge compound that bridges metabolic regulation and neuroprotection, offering new hope for treating Alzheimer’s disease and promoting healthy brain aging.