Ostarine (MK-2866)

Ostarine (MK-2866) – Premium Grade Selective Androgen Receptor Modulator (SARM)
CAS Number: 841205-47-8
Molecular Formula: C₁₉H₁₄F₃N₃O₃
Molecular Weight: 389.33 g/mol
Appearance: White to Off-white Solid

What is Ostarine (MK-2866)?
Ostarine, also known as MK-2866 or Enobosarm, is a cutting-edge selective androgen receptor modulator (SARM) designed to mimic the anabolic benefits of anabolic steroids without their androgenic side effects. This non-steroidal compound binds selectively to androgen receptors in muscle and bone tissue, making it a promising candidate for muscle wasting disorders, osteoporosis, and sarcopenia.

It also shows potential in regulating cardiomyocyte function, enhancing bone regeneration, improving uterine health, and positively influencing muscle tissue metabolism. These qualities position Ostarine as a powerful tool in both clinical research and performance optimization.

Mechanism of Action & Cellular Effects
Ostarine exhibits antiproliferative activity against various cancerous cell lines and demonstrates potent androgen receptor modulation:

Cell Line IC50 Effect

HEK293 0.0038 µM Strong antagonist activity at androgen receptor

DU-145 44.55 µM Anti-proliferative effect in prostate cancer cells

CWR22R 24.77 µM Anti-proliferative effect in prostate carcinoma

LNCaP 20.9 µM Anti-proliferative action in androgen-sensitive prostate cancer

VCaP 24.47 µM Proliferation inhibition in prostate tumor cells

In vitro studies indicate that Ostarine enhances the differentiation and proliferation of muscle cells:

H9C2 Cells: Ostarine (1000–10000 nM) significantly increases myosin protein production.

C2C12 & L6 Cells: Ostarine (1–10000 nM) promotes cell viability, proliferation, and muscle differentiation.

In Vivo Efficacy in Preclinical Models
In male Wistar rats, Ostarine (0.4 mg/kg for 30 days, administered subcutaneously) was observed to:

Stimulate muscle hypertrophy and enhance myogenic gene expression (Myogenin, MyH).

Trigger pro-fibrotic changes in cardiac tissue, with elevated markers like βMhc, Tgfβ, and Fibronectin.

These results highlight Ostarine’s anabolic potency, with implications for muscle recovery, rehabilitation, and tissue regeneration research.

Solubility & Preparation
Soluble in DMSO: ≥ 100 mg/mL (256.85 mM)

Due to its hygroscopic nature, use freshly opened DMSO for accurate solubility.

Stock Solution Preparation:

Concentration 1 mg 5 mg 10 mg

1 mM 2.5685 mL 12.8426 mL 25.6852 mL

5 mM 0.5137 mL 2.5685 mL 5.1370 mL

10 mM 0.2569 mL 1.2843 mL 2.5685 mL

Storage Guidelines
Form Temperature Stability

Powder -20°C 3 years

Powder 4°C 2 years

Solution -80°C 6 months

Solution -20°C 1 month

Ostarine Benefits (Research-Oriented)
Increases lean muscle mass

Enhances skeletal integrity

Promotes muscle repair and cell viability

Modulates androgen receptor activity without androgenic effects

Potential for cancer cell growth inhibition in vitro

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Disclaimer: This product is intended for laboratory research use only. Not for human consumption or therapeutic use.