Sacibertinib – Potent Tyrosine Kinase Inhibitor

Sacibertinib – Potent Tyrosine Kinase Inhibitor | CAS No. 1351941-69-9

Sacibertinib is a potent tyrosine kinase inhibitor used in cancer research. It works by targeting and blocking proteins like EGFR (EC₅₀: 110 nM) and HER2 (EC₅₀: 244 nM), which play key roles in tumor growth and cell signaling. Lab studies show that Sacibertinib effectively slows down the growth of various cancer cell lines, making it valuable for exploring targeted cancer therapies and EGFR/HER2-related pathways.

Whether you're studying breast, colorectal, or pancreatic cancer models, Sacibertinib is a reliable tool for advanced oncology research.

For research use only. Not for use in humans or clinical applications.

Molecular Formula: C₃₂H₃₁ClN₆O₄
Molecular Weight: 599.08 g/mol
Appearance: Solid
Applications: Tyrosine kinase inhibitor | Cancer research | EGFR/HER2 signaling pathway studies
For research use only. Not for human or clinical use.
Product Overview:

Sacibertinib is a highly selective tyrosine kinase (Trk) inhibitor that demonstrates potent inhibition of EGFR-TK phosphorylation (EC₅₀ = 110 nM) and HER2 (EC₅₀ = 244 nM). It exhibits promising antineoplastic activity, making it a valuable compound in cancer biology and therapeutic research targeting EGFR and HER2 pathways.
Key Biological Activities (In Vitro):

EGFR-TK Phosphorylation Inhibition: EC₅₀ = 110 nM

HER2 Inhibition: EC₅₀ = 244 nM

Growth Inhibition Activity:

Sk-Br-3 Cells: GI₅₀ = 3.8 nM

SW620 Cells: GI₅₀ = 1.78 μM

CCRF-CEM/T Cells: IC₅₀ = 5.6 μM

Fadu Cells: IC₅₀ = 101 nM

BxPc-3 Cells: IC₅₀ = 337 nM

AsPC-1 Cells: IC₅₀ = 1 μM

Note: Experimental data sourced from published studies. Accuracy not independently confirmed by MedChemExpress (MCE).

Storage & Shipping:

Shipping: Room temperature within the continental US (conditions may vary for international orders)

Storage: Follow guidelines provided in the Certificate of Analysis. Store in a dry, sealed container protected from light.

Sacibertinib Related Antibodies:

EGFR & HER2 Panel: EGFR (YA468, YA775), HER2 (YA388, YA771), Phospho-EGFR (Tyr1068, Tyr1092, Tyr1173)

Trk Family: TrkA, TrkB, TrkA+B+C, Phospho-TrkA/B (Tyr490/Tyr516)

Neurotrophin Receptors: NGF, p75 NGF Receptor

Other Targets: Caveolin-1, EGR1, c-Fos, GRB7, ErbB3/ErbB4

Available Sizes:

50 mg – Request quote

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250 mg – Request quote

Custom sizes available upon request

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